“Adventures in Metabolism” A symposium to celebrate Jeffrey Flier’s 70th Birthday
9:30-9:45 – Coffee
9:45-10:00 – Welcome, Opening Comments
10:00- 10:30 – Ron Kahn, Joslin Diabetes Center, HMS
“In the beginning, there was the insulin receptor”
10:30 – 10:55 - Barbara Kahn, BIDMC, HMS
“The Glut4 glucose transporter: after 3 decades still an oracle for understanding insulin sensitivity.”
10:55 – 11:20 – Rex Ahima, Johns Hopkins
“Metabolic factors driving weight regain after weight loss”.
11:20-11:45 – David Ludwig, Children’s Hospital Boston, HMS
“Which comes first, overeating or obesity?”
11:45-12:10 – Terry Maratos-Flier, BIDMC, HMS, Novartis
“FGF21: Deciphering a complicated metabolic hormone”.
12:10-1:00 – Lunch
1:00- 1:25 – Tony Vidal-Puig, U of Cambridge
“Adipose tissue expandability, lipotoxicity and Metabolic Syndrome.”
1:25- 1:50 – Erin Kershaw, U of Pittsburgh Med School
“A novel transcriptional regulator linked to energy and metabolic homeostasis in humans”.
1:50- 2:30 – Alan Moses, Novo Nordisk and David Moller, Sigilon Therapeutics
Moderator – Michael Rosenblatt – Flagship Pioneering
“Learnings from guiding scientific discoveries into therapeutic products in diabetes”
2:30- 2:55 – Joel Elmquist, UT Southwestern
"Ahima and Flier Revisited: Why do Leptin Levels Fall with Fasting?”
2:55- 3:20 – Maia Kokoeva, McGill U
“Structural basis of hypothalamic leptin sensing”.
3:20 - 3:45 – Break
3:45- 4:10 – Stephanie Fulton, U of Montreal
“Eat n’ Run: Leptin control of motivated behavior”
4:10- 4:35 – Brad Lowell, BIDMC, HMS
“Control of Hunger by Arcuate —> Paraventricular Hypothalamic Circuits”
4:35-5:15 – Steve O’Rahilly, U. of Cambridge
“Reflections from the Old World: the long reach of Jeff Flier”
5:15- 6:15 - Reception