SMART CLINICAL TRIAL DESIGN FOR TAILORED TREATMENT GUIDELINES
Presented by Kelley Kidwell, Ph.D., Associate Professor of
Biostatistics, University of Michigan School of Public Health Lunch
will be provided at 11:30. Remarks by Dr. Cathie Spino at 11:50 a.m.
and the LECTURE BY DR. Kidwell will begin promptly at 12:00 p.m. This
talk will introduce sequential, multiple assignment, randomized TRIAL
(SMART) DESIGN AS A TOOL TO BUILD EFFECTIVE, TAILORED INTERVENTION
GUIDELINES USED FOR THE PREVENTION OR TREATMENT OF DISEASES OR
DISORDERS OR FOR THE IMPLEMENTATION OF BEST PRACTICES. Diseases or
disorders such as substance abuse, depression, ADHD, autism, HIV/AIDs,
diabetes and cancer require sequences of TREATMENTS OVER TIME TO
ADDRESS CHANGING CHARACTERISTICS OF THE DISEASE AND THE PATIENT. These
TAILORED TREATMENT GUIDELINES ARE KNOWN AS DYNAMIC TREATMENT REGIMENS
(DTRs; also known as adaptive interventions) and are relevant to not
only treat, but also to prevent diseases or disorders or implement
best practices. DTRs provide GUIDELINES TAILORED TO THE INDIVIDUAL TO
ELICIT OVERALL OPTIMAL OUTCOMES. One way to build and compare DTRs is
by using a CLINICAL TRIAL CALLED A SEQUENTIAL, multiple assignment,
randomized TRIAL (SMART). A SMART IS A MULTI-stage CLINICAL TRIAL
WHERE EACH STAGE CORRESPONDS TO A CRITICAL DECISION POINT AND SOME
PARTICIPANTS MAY BE RE-randomized based on intermediate outcomes. The
same participants are followed throughout the TRIAL AS THEY FOLLOW A
SPECIFIC DTR. In this talk, we will introduce SMART DESIGNS AND
COMPARE THEM TO STANDARD TRIAL DESIGNS, provide guidance on the types
of questions that they can address, how to size such TRIALS, and
briefly introduce how to analyze a SMART TO FIND EVIDENCE FOR
EFFECTIVE DTRS. Kelley Kidwell is an Associate Professor of
Biostatistics. Kelley joined the University of Michigan after she
earned her doctoral degree in Biostatistics from the University of
Pittsburgh Graduate School of Public Health in 2012. Her research
centers on the DESIGN AND ANALYSIS OF CLINICAL TRIALS, especially
sequential multiple assignment randomized TRIALS. She is interested in
many collaborative areas including cancer, mental health, and rare
diseases. We would like to have you join in person, however, if
needed, please join US via BlueJeans link. Our aim is to provide an
outstanding experience for all attendees. If you require reasonable
accommodations in order to attend, please contact US at least 1 week
prior to the event. (Janine Capsouras - jleahcap@umich.edu or
763-1709)
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29/01/2020 Last update