SMART CLINICAL TRIAL DESIGN FOR TAILORED TREATMENT GUIDELINESPresented
by Kelley Kidwell, Ph.D., Associate Professor of Biostatistics,
University of Michigan School of Public Health
Lunch will be provided at 11:30. Remarks by Dr. Cathie Spino at 11:50
a.m. and the lecture by Dr. Kidwell will begin promptly at 12:00 p.m.
This talk will introduce sequential, multiple assignment, randomized
TRIAL (SMART) DESIGN AS A TOOL TO BUILD EFFECTIVE, TAILORED
INTERVENTION GUIDELINES USED FOR THE PREVENTION OR TREATMENT OF
DISEASES OR DISORDERS OR FOR THE IMPLEMENTATION OF BEST PRACTICES.
Diseases or disorders such as substance abuse, depression, ADHD,
autism, HIV/AIDs, diabetes and cancer require sequences of treatments
over time to address changing characteristics of the disease and the
patient. These tailored treatment guidelines are known as dynamic
treatment regimens (DTRs; also known as adaptive interventions) and
are relevant to not only treat, but also to prevent diseases or
disorders or implement best practices. DTRs provide guidelines
tailored to the individual to elicit overall optimal outcomes. One way
to build and compare DTRs is by using a clinical trial called a
sequential, multiple assignment, randomized trial (SMART). A SMART is
a multi-stage clinical trial where each stage corresponds to a
critical decision point and some participants may be re-randomized
based on intermediate outcomes. The same participants are followed
throughout the trial as they follow a specific DTR. In this talk, we
will introduce SMART designs and compare them to standard trial
designs, provide guidance on the types of questions that they can
address, how to size such trials, and briefly introduce how to analyze
a SMART to find evidence for effective DTRs.
Kelley Kidwell is an Associate Professor of Biostatistics. Kelley
joined the University of Michigan after she earned her doctoral degree
in Biostatistics from the University of Pittsburgh Graduate School of
Public Health in 2012. Her research centers on the design and analysis
of clinical trials, especially sequential multiple assignment
randomized trials. She is interested in many collaborative areas
including cancer, mental health, and rare diseases.
We would like to have you join in person, however, if needed, please
join US via BlueJeans link [https://bluejeans.com/875089279].
Our aim is to provide an outstanding experience for all attendees. If
you require reasonable accommodations in order to attend, please
contact US at least 1 week prior to the event. (Janine Capsouras -
jleahcap@umich.edu or 763-1709)
art
food
1757
Views
29/01/2020 Last update