GASTRIC INHIBITORY POLYPEPTIDE (GIP) is an important metabolic hormone
in animals. INTRODUCTION OF GASTRIC INHIBITORY POLYPEPTIDE
[https://www.creative-peptides.com/product/gastric-inhibitory-polypeptide-and-fragments-18.html]
Gastric inhibitory polypeptide (GIP) is an important metabolic hormone
in animals. It has a special molecular structure and plays an
important physiological role in animal organisms. GIP is an incretin
synthesized and secreted by the enteroendocrine cell-K cells in the
upper part of the small intestine of the mammal and is an important
member of the gastrointestinal regulatory peptide secretin family. GIP
was originally isolated in the pig intestines and inhibits the
secretion of gastric acid. The half-life of GIP in plasma is shorter,
less than 2 min in mice and 7 and 5 min in normal and type 2 diabetic
patients, respectively. The highest concentration in the jejunum and a
certain amount of secretion in the duodenum and ileum. Its
physiological role is inhibition of gastric acid secretion; inhibition
of pepsin secretion; stimulation of insulin release; inhibition of
gastric peristalsis and emptying; stimulation of intestinal secretion;
stimulation of glucagon secretion.
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16/10/2019 Last update